The research interests (since 1989) have comprised in-vitro, ex-vivo and in-vivo studies for answering to some biochemical/physiological questions and the consequent translation of the scientific findings from the cell/tissue/organ to the whole human organism. Furthermore, over the last years Quaresima has been paying attention on the development and the application in biomedical field of the imaging modality which relies on the detection of "photons" as a basis for image formation (molecular imaging). The wide research activity (mainly performed with an interdisciplinary approach and in collaboration with international and national scientists) has mainly involved: 1) biochemical and biophysical (in-vitro, ex-vivo, and in-vivo) studies on the nitric oxide and the antioxidant role of the ascorbate; 2) biochemical and biophysical (in-vitro and in-vivo) studies on metalloproteins with a particular attention on the major respiratory proteins that react with oxygen (hemoglobin and cytochrome oxidase); 3) in-vivo studies for investigating the oxidative metabolism in human skeletal muscle and human brain cortex; 4)development, validation and pre-clinical/clinical testing of advanced non-invasive optical molecular imaging devices based on the use of continuous wave, time-resolved and phase-modulation fiber optic near-infrared spectroscopy (NIRS); 5) expansion of in-vivo Biochemistry in understanding human cortex functions (cognitive neuroscience).