I have spent my entire research career studying the regulation of the circulation and metabolism of the brain, the interaction of neurotransmitters and membrane lipids in response to temperature, global and focal brain ischemia and traumatic brain injury (TBI), their pathogenesis and therapy in both laboratory and clinical research. My current focus is on the role of microvascular shunts In the loss of CBF autoregulation as it relates to stroke and traumatic brain injury. Most recently, I have focused on the flow promoting effects of high molecular weight drag reducing polymers as a therapeutic approach in cerebrovascular disease and stroke.